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A guest post from Kat Sanders. She regularly posts at The Pharm Tech Blog.

There are many reasons to be grateful to technology and the millions of ways it has made life easier and more comfortable for all of us.

We cannot imagine a world without technology today, because it has crept into every aspect of our lives and made itself indispensable in more ways than one.

Not many people (unless they’re die-hard technophobes) have anything against technology, but if there’s one grouse I have, it’s that the hundreds of thousands of wonderful invention of mankind have contributed to the comprehensive dulling of the human brain.

When you think of it, our brain cells have less work to do because of the conveniences that technology offers us:

  • We don’t remember things that we used routinely commit to memory: How many of us bother to remember phone numbers of friends and family members when it’s just easier to dial them from the contact lists on our mobile phones? And how many of us keep directions in mind after the advent of the wonder we call GPS? You have to admit that technology has made things easier for the idiots among us, but it has not done anything useful for the longevity and continued health of our neurons.
  • Everything is handed to us on a platter that we don’t have to work for it anymore: With the Internet and related technology, searching for information has become so much easier than it was a decade ago. While you would think this is a good thing, what we do not realize is that there is a surfeit of information out there and not many of us bother to check which sources are authentic and which are not. This is because information is being handed to us without us having to go in search of it, without our brains being involved, that we stop questioning its veracity.
  • Mindless activities are replacing intelligent ones: Technology and gaming have come together to bring violence and action into our lives. While games, those of the indoor kind, were supposed to keep your brains in working order in another life, today, they serve to exercise nothing except your hand and eyes. Your brain is hardly involved, and you react instinctively rather than intelligently.

With the high occurrence of mental illnesses like Alzheimer’s and other degenerative brain diseases, it’s time to focus on mental health and on activities that help improve you’re cognitive and memory functions.

By-line:
This article is written by Kat Sanders, who regularly blogs on the topic of pharmacy tech certificate at her blog The Pharm Tech Blog.  She welcomes your comments and questions at her email address: katsanders25@gmail.com.

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That’s right – the food industry has turned us into junkies.
We crave fat, salt and sugar. This is not part of our DNA. It’s an addiction that we have acquired over the past couple of decades.

endofovereating

David Kessler, the former head of the Food and Drug Administration has written a book called “The End of Overeating: Taking Control of the Insatiable American Appetite.” It addresses the problem of obesity in our society and how the food industry has been contributing to our craving for unhealthy food.

Dieting doesn’t work.

Kessler wanted to understand why people continue to eat even when they are no longer hungry.

“Why is it that Americans continue to crave such foods as potato chips and candy bars long after they feel full? No one has ever explained what’s happening to them and how they can control their eating,” he says in his book.

Kessler is a 57-year-old pediatrician and professor of pediatrics at the University of California, San Francisco.

He was commissioner of the FDA from 1990 to 1997. He worked hard to improve the labeling of food products and was a vocal opponent of the tobacco industry.  In fact he should get a lot of credit for the recent successful legislation that gives the FDA the responsibility to regulate tobacco products.

Kessler found that there’s a “bliss point” – a combination of sugar, fat and salt – that makes a food practically irresistible.

He says that those ingredients excessively activate the rewards circuits of the brain. They over-stimulate the rewards-circuitry of the brain.

Can you order healthy food in restaurants?

Kessler says “Much of what we eat in restaurants is fat on fat on sugar on fat with salt. Pick any dish in any mid-American restaurant. What is spinach dip? Fat on salt with green stuff. Look at the average salad we’re eating. If you look at the bacon, the croutons, the cheese – it’s fats, salts and a little lettuce.”

He warns that we are conditioned by the food, that it actually affects the motivational circuits in our brains. We get conditioned as kids when we eat tons of fat, salt and sugar all the time. Eventually the neuro-circuitry gets laid down and it stays with us for life.

Plus there are plenty of cues – visual cues, ads, fast food available everywhere. This stimulus activates your craving and you want food when you aren’t even hungry.

Some food industry executives admit that fat, salt and sugar are the key components of a successful food product.

So the food industry designs highly stimulating products, and consumers come back for more. Nothing sells as much as something that stimulates the rewards-circuitry of the brain. It’s all about selling product.

The solution for Dr. Kessler is not more regulation but changing the perception of bad food.  That’s what happened with cigarettes. Eventually people got turned off by the dangers of smoking. That can happen with the consumption of unhealthy food as well.

Remember the movie Super Size Me?

The director Morgan Spurlock described (after a few weeks of only eating at McDonald’s) how he felt after a McDonald’s meal. He thought it was a lot like how a junkie must feel after shooting heroin.

Right away you feel great as the fat, salt and sugar kicks in and your system goes into overdrive. Soon, after the stuff wears off, you fell like hell – tired, lethargic, cranky. Time for another fix.

There’s a good interview with Dr. Kessler in the Wall Street Journal here.

And a good interview on Minnesota Public Radio here.

Want to get your mind off of food? Try playing a casual game or two. We’ve got plenty at our web site – Brain Games Software. And none of our games contain any fat, salt or sugar.

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Sure why not.  We could all use some good news these days.

ice-cream-sundae

It seems that fat-rich foods can trigger long term memory.

I can attest to that.  I can remember the last gelato I had like it was minutes ago.  Well, actually it was.

In any case University of California at Irvine researchers have found that oleic acids from fat turn into a compound called (remember this for your spelling bee) oleoylethanolamide (OEA).

This OEA is great stuff.  First of all it sends a message to your brain that you are full so you don’t keep eating that entire gallon of chocolate mint chip ice cream.

Fat is a wonderful thing?

It can also reduce your appetite, produce weight loss and lower blood cholesterol and triglyceride levels. (Are we talking about fat here?)

Short-term to long-term memories

Best of all the researchers found that OEA can cause short-term memories to transform into long-term memories.  Pretty amazing stuff because it’s generally pretty hard to push those fleeting memories into the hard wired amygdala section of your brain.

The research team, lead by Daniele Piomelli, the Louise Turner Arnold Chair in Neurosciences, and Professor James McGaugh from UCI, reported that this was probably more important to our ancestors.

“Remembering the location and context of a fatty meal was probably an important survival mechanism for early humans,” Piomelli said.

Today that might not be as beneficial. While OEA contributes to feelings of fullness after a meal, it could also create long-term cravings for fatty foods which, we all know, can cause obesity.

Study results appear in the online edition of the Proceedings of the National Academy of Sciences. You can read a brief article on the Science Daily web site.

Here’s some more good news.  Playing casual games can relieve stress, and they are not fattening.  We’ve got lots of games at our site, Brain Games Software.  Come by and visit.

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Believe it or not, this task is a powerful predictor about your future.

marshmallows

There was a great article in the May 18th issue of the New Yorker about experiments to figure out why some people are able to delay gratification while others cannot.

It seems trivial but “delayers” – people who can control their gratification seem to do better in life than folks who can’t control their need for instant gratification.

It all started in the 1960’s with the marshmallow task at the Bing Nursery School, on the campus of Stanford University. Walter Mischel, a Stanford professor of psychology was in charge of the experiment.

One marshmallow now or two later.

Kids were brought into a room by themselves and asked to sit down in a chair and pick a treat from a tray of marshmallows, cookies, and pretzel sticks.

They were told they could either eat one of the treats right away or, if they were willing to wait while he stepped out for a few minutes, they could have two treats when he returned.

Mischel and his research team were hoping to identify the mental processes that allowed some people to delay gratification while others simply surrendered.

The researchers have continued to track the participants in that study. In 1981 they sent questionnaires to the parents and teachers of the 650 subjects, who were by then in high school. Here’s some of the follow up findings:

He noticed that subjects that were not able to delay their gratification seemed more likely to have behavioral problems, both in school and at home. They got lower S.A.T. scores. They struggled in stressful situations, often had trouble paying attention, and found it difficult to maintain friendships.

Higher IQ scores

The child who could wait fifteen minutes had an S.A.T. score that was, on average, two hundred and ten points higher than that of the kid who could wait only thirty seconds.

Mischel and his team are hoping to identify the particular brain regions that allow some people to delay gratification and control their temper which will allow them to outline the neural circuitry of self-control. For decades, psychologists have focused on raw intelligence as the most important variable when it comes to predicting success in life.

Many of the kids who successfully delayed their gratification (and got two marshmallows later on) did so by distracting themselves from the treat at hand. Some turned their back to the treats so they didn’t have to think about it.

A matter of self control

Children who were better able to delay gratification seemed to have an accurate understanding of the workings of self-control.

In adults, this skill is often referred to as metacognition, or thinking about thinking, and it’s what allows people to outsmart their shortcomings.

To Mishcel the task is powerfully predictive. It’s not about marshmallows, it’s about studying instead of watching TV; it’s about saving for retirement instead of blowing your savings on a vacation.

According to Mischel, even the most mundane routines of childhood—such as not snacking before dinner, or saving up your allowance, or holding out until Christmas morning—are really sly exercises in cognitive training: we’re teaching ourselves how to think so that we can outsmart our desires.

Caltech study of dieters

There is also a new study from the California Institute of Technology (Caltech) which has uncovered differences in the brains of people who are able to exercise self-control versus those who find it almost impossible.

The results of that study were published in the May 1 issue of Science Daily.

Scientists used the interplay between self-control and decision making in dieters to uncover differences in the brains of people who are able to exercise self-control versus those who find it almost impossible.

Both articles are great reads and might even give you the wherewithal to hold on and wait for that second marshmallow.

By the way, if you want another way to get your mind off marshmallows (I’m thinking a s’more would be pretty good about now) a good brain stimulating game might do the trick. We’ve got lots of them at our web site, Brain Games Software.

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Man, am I relieved. Multi-tasking is apparently a myth.
texting4

I keep trying to text while I’m studying, watching a movie and updating my Facebook account.

But, I just can’t remember anything. I’m ashamed to be a multi-tasking failure.

Fortunately, in a single-tasking moment, I read this excellent article by John Tierney in the New York Times (the paper version that I’m paying for to help keep the print media in business so we can continue to have a fourth balancing check in our democracy. Opps, sorry, that’s another rant for another day).

It’s actually an article about our ability to concentrate – the science of paying attention.

It focuses on a book by Winifred Gallagher called Rapt. Attention and the Focused Life.

Block it out

She says we should recognize our brain’s finite ability to process information. Block out all the distractions (TV, email, tweets, iPods, cell phone calls, etc.) and try to enjoy one thing at a time to its fullest. Or be completely ensnarled in multimedia noise and enjoy nothing.

Easier said than done according to Dr. Robert Desimone, the director of the McGovern Institute for Brain Research at the Massachusetts Institute of Technology.

He says “It takes a lot of your prefrontal brain power to force yourself not to process a strong input like a television commercial. If you’re trying to read a book at the same time, you may not have the resources left to focus on the words.”

Their goal, along with other neuroscientists, is to find therapies that can strengthen our attention spans. (Hmm, so that we can better multi-task?)

They are experimenting with pulses of laser light shined through tiny optical fibers onto genetically engineered neurons in mice. It may help to better synchronize neurons that will allow for improved concentration.

Here’s some more questions and answers from Dr. Desimone on the New York Times site:

Skipping the sci-fi approach, Gallagher had some low tech suggestions that you can do in your own home, without the aid of a neuroscientist.

You can meditate

For starters she says researchers have observed higher levels of synchrony in the brains of people who regularly meditate.

Here’s what she suggests for a productive day: spend the first 90 minutes of the day on your most important task. After that your prefrontal cortex needs a rest so that’s a good time to do less mind challenging tasks like answering email, phone calls and playing Tetris.

If you get distracted during that productive 90 minutes, it can take 20 minutes just to get back to what you were focused on. She has more advice at this link.

Like a drug

One important point she makes: these things that distract us are stimulants, which we can become hooked on. Like dieting, information consumption is a matter of self control.

“Multitasking is a myth,” Ms. Gallagher said. “You cannot do two things at once. The mechanism of attention is selection: it’s either this or it’s that.”

“People don’t understand that attention is a finite resource, like money,” she said. “Do you want to invest your cognitive cash on endless Twittering or Net surfing or couch potatoing?

Not me. I’m not going to squander my precious cognitive cash on this stuff anymore. I’m going to try to focus on and enjoy one thing at a time.

And now my prefrontal cortex needs a rest so I’m going to play some casual video games. Want to play? Check out our games at Brain Games Software.

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What if you could erase some of your worst memories – you know the stuff that makes you cringe when it pops up in your head.

memories2

Researchers at the SUNY Downstate Medical Center, in Brooklyn, NY might be able to help you out with a dose of a drug that effects areas of the brain that retain memory.

Dr. Todd C. Sacktor, a neuroscientist who heads the research team, believes this could be a useful drug for treating trauma, addiction, fear, and other behaviors.  Maybe it could even break a bad habit or two.

Basically the drug blocks the activity of a substance that the brain needs to retain information.

While this is significant, the bigger issue, which is raised in a recent New York Times article by Benedict Carey: how can our brains capture and retain so much, from the most important, life altering information to the utterly mundane?

This is explained by the term engram, which is the hypothetical means by which memories are stored as biochemical change in response to external stimuli.  And memories are not stored in one place but throughout the cortex.

How does it work?

It’s likely that a large network of brain cells is at work creating and retaining memories. When activated by an experience, each cell adds some detail, like sight, sound and smell to create or recall the memory.  Memories are retained because the lines of communications between these cells grow stronger and thicker.

Dr. Sacktor’s lab found that a molecule called PKMzeta was present and activated in cells precisely when one cell stimulated another while creating these lines of communications.

Once they isolated the molecule, they experimented with a drug called ZIP that interferes with PKMzeta. Using mice that had learned to avoid electric shocks, the injection of ZIP caused the mice to completely forget how to avoid the shocks.

Since that first experiment they have been working with a consortium of researchers to recreate the results using a number of different methods, achieving similar results.

Of course this needs a little more refinement.

It’s too early in the research process to predict that neurologists will develop a tool to selectively erase memories.

It would be tempting to erase all the painful memories of the past.  Of course there’s the possible downside of forgetting really important personal memories, even if they are painful.

And sometimes painful memories act as reminders of bad behavior which can help you maintain your moral conscience.

I don’t know if I’m willing to shed all my bad memories but I’d sure hate to lose the good ones.

By the way, how is your memory?  We’ve got lots of casual games at our website – Brain Games Software – where you can give it a workout.

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The supermarkets are full of it – enhanced bottled water.  Are they any good?

Nutritionist Dr. Pamela Peeke believes that some of the claims that marketers make about enhanced water may not be true.

water_glass21

For example, she says you can drink water with added oxygen, like Active 02, or you can get ten times as much oxygen into your system by simply breathing.  Something I try to do all day.

What else do you get?

Sugar and calories.  For example Vitamin Water is the best-selling enhanced water in the US.  Along with vitamins you get 32.5 grams of sugar in a 20 oz. bottle according to Dr. Peeke.

She is also skeptical about brain enhancing water like Brainiac which was developed by Function, a bottler founded by an orthopedic surgeon named Dr. Alex Hughes.

Dr. Hughes says Brainiac will “boost your memory and mental sharpness,” because it contains ingredients like soy PS, zinc and ginkgo biloba.

Function cites a host of supportive studies to bolster its claims, but the studies are of the ingredients and not the drinks.

The ABC News show “20/20” initiated a small test done by Dr. Thomas Crook at the Cognitive Research Corporation in St. Petersburg, FL.  He tested 12 people to see if drinking a bottle of Brainiac would improve their memory.

They were given a few basic memory tests before consuming the drink or a placebo (Hawaiian Punch) and took the memory tests again after consuming the beverages.

Surprising results?

Actually the Hawaiian Punch drinkers did a bit better than the Brainiac drinkers.

Function’s response was Dr. Crooks experiment generated “no statistically significant findings” because there were only 12 test subjects.

Dr. Crook said that even though the test was small, the results didn’t surprise him.

“The amount of PS, the amount of ginkgo they’re adding to the product. They’re so small that no one has ever shown any effect.”

A big beverage category

The enhanced water category has become a $1.5 billion industry, with more than 150 products available, says Barry Nathanson, editor of the trade publication Beverage Spectrum.  I don’t know – maybe we should stick with the Hawaiian Punch.

OK we know that some software publishers claim that their products can also enhance cognitive abilities.  At Brain Games Software we think playing casual computer games can be fun, relaxing and mentally stimulating.  Beyond that who knows.  I’ll drink (some water) to that.

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Someday you might be wearing a hat that will send electrical current to your brain.

tmsmachine1

In my last blog I wrote about a form of neuroengineering in which a fiber optic cable is implanted in the brain to treat certain disorders such as severe depression. (Inexplicably I haven’t heard from any readers who have rushed out to try this therapy.)

OK – how about trying transcranial magnetic stimulation, fondly called the TMS machine?

It’s a process that neurologists are testing that uses electrical current to stimulate parts of the brain.  This process is a whole lot less invasive than sticking a cable into your brain.

Dr. Ed Boyden is a researcher with a neuroengineering lab at the Massachusetts Institute of Technology Media Lab.  He built the TMS machine.  If you hold it to your head it can electrically affect areas of the brain that are very close, within a few centimeters, of the skull.

edboyden

Because nerves run on electricity, they will respond to electronic impulses. So the TMS machine is used to deliver a mild amount of electricity to nearby nerves in the brain.

Researchers have used the TMS to treat migraine headaches and depression as well as inducing savant-like skills and causing people to take greater risks.

There was an article in Wired recently with details and, I love this, the writer agrees to try this machine out.

Actually, Dr. Boyden says that transcranial magnetic stimulation is safe for use as a neurological therapy or research tool and its effects are temporary.

So what’s the potential application for these machines?

Maybe it can be used to boost creativity at will since it can increase concentration and risk-taking.  Maybe it can be useful as a portable device that can treat severe depression or other neurological disorders, instead of pumping a lot of meds into a person. And perhaps there are other applications for controlling our own brain that we haven’t really thought of yet.

Speaking of electrical stimulation of the brain, here’s another form that’s proven to be fun and relaxing: playing casual games on your computer.  We’ve got lots of them at our Brain Games Software website.

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Neuroengineers are working on procedures to physically rewire the brain.  In doing so, they can control behavior.

brain1

OK, have I seen this movie?

This new science of neuroengineering was covered in a two-part article in Wired magazine recently.

It sounds scary but scientists claim that there is a very sound application for this procedure.

This work is being done at the Stanford University lab of Dr. Karl Deisseroth.

Basically, here’s what they are doing – with mice of course.

Researchers modify a harmless, non-reproducing virus to add genes to a particular type of cell. The genes come from two sources – an algae and an archeon – which respond to light.

The virus is inserted into the brain of a mouse and attached to a fiber optic cable.  A laser can send specific frequencies of light through the cable which can turn the cells on and off.  This stimulates the brain in various ways.

Depending on the area of the brain being stimulated, it can affect motor activity, mood, or other brain functions.

This involves a lot of scientists including biologists, an ecologist, a geneticist, a neurologist, a surgeon, a laser physicist and a bioethicist, who’s taking a look at the moral issues of electrically modifying someone’s personality.

Treating depression

Maybe this isn’t a therapy recommended for everyone but Deisseroth contends that this may be a valid treatment for severe depression.

Treatment for depression is often done shotgun style.  That is the patient is given antidepressant drugs which go everywhere in the body.

These psychoactive drugs often have to be delivered in high concentrations into the blood in order to get past the blood-brain barrier.  This often causes unpleasant and dangerous side effects.  And the drugs affect all parts of the brain, not just the specific area that needs treatment.

While the idea of engineering the brain might seem bizarre or unethical, Deisseroth says that if your brain is broken, you just want it fixed which he says especially applies to people suffering from depression.

It’s his view that by isolating and testing parts of the brain, researchers can ultimately understand what the components do and potentially enhance those parts while leaving the rest of the brain untouched.

I can recommend another type of brain stimulus that’s available now and requires no fiber optic cable inserted into your brain.  Go to our website – Brain Games Software – where you will find lots of brain stimulating games.

Some good blogs I’ve come across this week:
The Daily Galaxy, bills itself as news from planet earth and beyond.

Out of Bounds which advises “make each moment count double.”

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There’s a revolutionary new search engine due to come online in May that may be able to compute the answers to questions that you ask in natural language.

wolfram-alpha-search-bar2

It’s more accurately called a computational knowledge engine.

What’s the big deal?

Basically Google (or any search engine) finds information that has been published. Essentially it just looks things up.

But this new search engine – called Wolfram Alpha – actually computes the answers to questions. The computational knowledge engine was created by Stephen Wolfram.

stephenwolfram

Google provides answers to questions people have already asked. Wolfram Alpha synthesizes answers to questions nobody has asked.

Natural language

Questions, which you can ask in natural language, are broken down into basic parts. Answers are computed based on the enormous knowledge base.

Wolfram claims that the engine can make inferences, it can do basic reasoning and can synthesize new knowledge. This is remarkably different from a search result that simply produces data that might contain the answer to your question.

Wolfram has created a proprietary system of knowledge fields made up of terabytes of data and millions of lines of algorithms that represent real-world knowledge.

There’s more detail at Wolfram’s blog.

And search engine expert Nova Spivack has written on his blog that Wolfram Alpha could be as important as Google. He considers this the next step in the distribution of knowledge and intelligence around the world. Read his informative post here.

And keep your eye on the Wolfram Alpha site which launches in May.

Wolfram’s bio is here.

While you are waiting patiently for the launch of this interesting new site you might find you have a few spare moments to play a casual, mind stimulating game or two. If so check the vast selection on our web site, Brain Games Software.

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